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Blood Pressure
    Home > Blood Pressure > Coversyl Plus (Perindopril + Indapamide)

Coversyl Plus (Perindopril + Indapamide)
Select Ref Description Manufacturer Pack Size Strength Our Price
P1096 Coversyl Plus (Perindopril + Indapamide) Serdia 10 tabs 4 mg+1.25 mg $ 9.00
J85 Coversyl (Perindopril arginine) Generic 10 tabs 2 mg $ 6.75
P1093 Coversyl (Perindopril) Serdia 10 tabs 2 mg $ 5.85
P1094 Coversyl (Perindopril) Serdia 10 tabs 4 mg $ 7.65
P1095 Coversyl (Perindopril) Serdia 10 tabs 8 mg $ 8.64
J86 Coversyl (Perindopril arginine) Generic 10 tabs 4 mg $ 8.55
J495 Indapamide Generic 10 tabs 1.5 mg $ 7.51
P1164 Lorvas (Indapamide) Torrent 10 tabs 2.5 mg $ 7.51
P1163 Lorvas SR (Indapamide) Torrent 10 tabs 1.5 mg $ 6.66
J210 Lozol (Indapamide) Generic 10 tabs 1.5 mg $ 7.96
J211 Lozol (Indapamide) Generic 10 tabs 2.5 mg $ 7.90
Price is per pack & not per tab.. eg: if pack size is 10 tabs & price is $2.75 then for 100 tabs the price would be $27.50

How does it work?

Coversyl arginine tablets contain the active ingredient perindopril, which is a type of medicine called an ACE inhibitor. (NB. Perindopril is also available without a brand name, ie as the generic medicine.)

ACE inhibitors work by blocking the action of a compound in the body called angiotensin converting enzyme (ACE). Normally ACE produces another compound called angiotensin II, as part of the body's natural control of blood pressure. Angiotensin II causes blood vessels to constrict and narrow, which increases the pressure within the blood vessels.

As perindopril blocks the action of ACE, it reduces the production of angiotensin II. This means that the blood vessels are allowed to relax and widen. The overall effect of this is a drop in blood pressure, hence perindopril can be used to lower high blood pressure.

The reduced pressure within the blood vessels means that the heart doesn't have to work as hard to pump the blood around the body. This means that ACE inhibitors can be used to improve the symptoms of heart failure, where the heart is not pumping as efficiently, and to improve survival following a heart attack.

It is recommended that Coversyl arginine tablets are taken in the morning before breakfast.

What is it used for?

Heart failure.
High blood pressure (hypertension).
Reducing the risk of further heart attacks in people with stable coronary heart disease who have had a heart attack or heart bypass surgery.


Coversyl arginine tablets replaced Coversyl tablets in April 2008. Coversyl arginine tablets contain a different salt of perindopril to the old Coversyl tablets (perindopril arginine instead of perindopril tert-butylamine). This new salt has an extended shelf-life and greater stability. Coversyl arginine is equivalent to the old Coversyl in terms of safety and effectiveness, and the action of the medicine has not changed. However, the new tablets come in different packaging and in different strengths to the old Coversyl tablets. Coversyl arginine 2.5mg tablets are equivalent to the old Coversyl 2mg tablets. Coversyl arginine 5mg tablets are equivalent to the old Coversyl 4mg tablets and Coversyl arginine 10mg tablets are equivalent to the old Coversyl 8mg tablets. Generic perindopril tablets remain available; these contain the tert-butylamine salt. Coversyl arginine 2.5mg tablets are equivalent to generic perindopril 2mg tablets. Coversyl arginine 5mg tablets are equivalent to generic perindopril 4mg tablets and Coversyl arginine 10mg tablets are equivalent to generic perindopril 8mg tablets. If you have any questions or concerns about this change you should talk to your pharmacist.

Some people may experience dizziness caused by low blood pressure in the first few days of taking this medicine and in particular the first dose. For this reason, the first dose should preferably be taken at bedtime. Your doctor may want you to take the first dose of this medicine under medical supervision in hospital if you are aged over 70 years, have low blood pressure, low levels of fluids or salt in your blood (eg due to dehydration), severe or unstable heart failure, kidney problems, or are taking high doses of diuretic medicines, multiple diuretic medicines, or certain other medicines that dilate your blood vessels.

If you feel dizzy during treatment this can be relieved by lying down until the symptoms pass. If affected you should avoid performing potentially hazardous tasks such as driving or operating machinary. If you frequently feel dizzy you should let your doctor know, as your dose may need reducing.

Alcohol may enhance the blood pressure lowering effect of this medicine, which can increase dizziness and may increase the risk of fainting.

ACE inhibitors can sometimes cause an allergic reaction called angioedema. Stop taking this medicine and consult your doctor immediately if you experience difficulty breathing or swallowing, or swelling of your face, lips, tongue, throat, hands, feet or ankles while taking this medicine. This type of allergic reaction has been reported more frequently in people of Afro-Caribbean origin.

Your blood pressure, kidney function and the amount of potassium in your blood should be regularly monitored while you are taking this medicine.

Use with caution in

Elderly people.
Decreased liver function.
Decreased kidney function.
Narrowing of the arteries that supply blood to the kidneys (renal artery stenosis).
High blood pressure caused by compression or blockage of the arteries that carry blood to the kidneys (renovascular hypertension).

People with low fluid volume or salt levels in the body, eg due to diuretic therapy, low-sodium diet, diarrhoea or vomiting.

People taking other medicines for high blood pressure, particularly diuretics (see end of factsheet).

People with hardening of the arteries (athersclerosis) in the heart (cardiovascular disease), brain (cerebrovascular disease) or legs (peripheral vascular disease)

Narrowing of the main artery of the body (aortic stenosis).
Heart valve disease (mitral valve stenosis).
Heart disease characterised by thickening of the internal heart muscle and a blockage inside the heart (hypertrophic obstructive cardiomyopathy).

Diseases affecting connective tissue, eg scleroderma, systemic lupus erythematosus or rheumatoid arthritis (collagen vascular diseases).

People with kidney failure requiring a certain type of haemodialysis (high-flux membrane).
People undergoing therapy to decrease allergy to bee or wasp stings (desensitisation).
People receiving therapy to remove certain types of fat from the blood using a machine (LDL apheresis).

Not to be used in:

Allergy to other ACE inhibitor medicines.
History of swelling of the lips, face or tongue (angioedema) with no known cause, or caused by previous use of an ACE inhibitor medicine.

Hereditary angioedema (angioneurotic oedema).
Rare hereditary problems of galactose intolerance, glucose-galactose malabsorption, or the Lapp lactase deficiency (Coversyl arginine tablets contain lactose).

The safety and efficacy of this medicine in children have not been studied. It is not recommended for children.

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

This medicine must not be used during pregnancy, particularly during the second and third trimesters, as it may be harmful to the unborn baby. Seek further medical advice from your doctor. If you get pregnant while taking this medicine, stop taking it and consult your doctor immediately.

This medicine passes into breast milk. The manufacturer states that it should not be taken by women who are breastfeeding. Seek further medical advice from your doctor.

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.

Common (affect between 1 in 10 and 1 in 100 people):

Pins and needles sensations.
Low blood pressure (hypotension).
Visual disturbances.
Sensation of ringing or other noise in the ears (tinnitus).
Dry cough.
Shortness of breath.
Disturbances of the gut such as diarrhoea, constipation, indigestion, nausea, vomiting or abdominal pain.
Alteration in taste.
Rash or itching.
Muscle cramps.
Feeling of weakness.

Uncommon (affect between 1 in 100 and 1 in 1000 people):

Sleep disturbances.
Changes in mood.
Dry mouth.
Severe swelling of lips, face, tongue or throat (angioedema - see warning above).
Problems with kidney function.

Very rare (affect less than 1 in 10,000 people):

Chest pain.
Inflammation of the pancreas (pancreatitis).

Disturbances in the normal levels of blood cells in the blood (tell you doctor if you get a sore throat, mouth ulcers, high temperature (fever), or feel tired or generally unwell while taking this medicine).

Problems with liver function, including jaundice or hepatitis (consult your doctor promptly if you develop unexplained itching, yellowing of the skin or eyes, unusually dark urine, nausea and vomiting, abdominal pains, loss of appetite or flu-like symptoms while taking this medicine).

The side effects listed above may not include all of the side effects reported by the medicine's manufacturer.For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?

It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.

This medicine will have an additive effect with other medicines that decrease blood pressure, particularly other medicines used to treat high blood pressure (antihypertensives). In people taking antihypertensive medicines it may cause a large drop in blood pressure with the first dose or after any dose increases, particularly in people taking diuretic medicines such as furosemide. This may cause dizziness, which can usually be relieved by lying down until the symptoms pass. If you are taking a diuretic medicine, your doctor may reduce your dose or ask you to stop taking it for a few days before starting perindopril. This is to prevent your blood pressure from dropping too low. If you frequently feel dizzy while taking this medicine in combination with other blood pressure lowering medicines you should let your doctor know, as your doses may need adjusting.

Other medicines that decrease blood pressure include the following:

ACE inhibitors such as enalapril
alpha-blockers such as prazosin
angiotensin II receptor antagonists such as losartan
benzodiazepines, eg diazepam, temazepam
beta-blockers such as propranolol
calcium channel blockers such as nifedipine, diltiazem
diuretics, eg furosemide, bendroflumethiazide
dopamine agonists, eg bromocriptine, apomorphine
MAOI antidepressants, eg phenelzine
nitrates, eg glyceryl trinitrate.
Non-steroidal anti-inflammatory drugs (NSAIDs, eg indometacin, aspirin, ibuprofen) may reduce the blood pressure lowering effect of perindopril, and may increase the risk of a decline in kidney function.

There may be a risk of raised potassium levels in the blood (hyperkalaemia) if any of the following medicines are taken with perindopril, hence these are not normally recommended for use in combination with perindopril. If you are taking any of the following with this medicine you should have regular blood tests to monitor the amount of potassium in your blood:

angiotensin II receptor antagonists, eg losartan
potassium-containing salt substitutes (eg Lo-Salt)
potassium salts, eg potassium citrate for cystitis
potassium-sparing diuretics (eg spironolactone, triamterene, amiloride)
potassium supplements.
Perindopril may increase the blood level of the medicine lithium and for this reason, it is not normally recommended for people taking lithium. People taking this medicine in combination with lithium should have the level of lithium in their blood closely monitored.

Perindopril may enhance the blood sugar lowering effect of insulin and oral antidiabetic medicines, and may increase the risk of low blood sugar (hypoglycaemia). People with diabetes should therefore carefully monitor their blood sugar while taking this medicine, particularly in the first few weeks of treatment.

There may be an increased risk of a drop in the normal numbers of blood cells in the blood if this medicine is used in combination with any of the following medicines:

immunosuppressant therapy

If you are taking any of these in combination with this medicine, you should have regular blood tests to monitor the levels of your blood cells, particularly if you also have any kidney problems or diseases affecting connective tissue, eg scleroderma, systemic lupus erythematosus or rheumatoid arthritis (collagen vascular diseases). Tell your doctor if you experience any signs of infection, such as fever, sore throat or mouth ulcers, as these could be signs of problems with your white blood cells.


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