Indications
Cefoprox is indicated for the treatment of the following infections:
Upper respiratory tract infections, including acute otitis media, tonsillitis and pharyngitis.
Acute exacerbations of chronic bronchitis.
Acute community-acquired pneumonia.
Acute uncomplicated gonorrhoea.
Uncomplicated urinary tract infections.
Uncomplicated skin and skin structure infections
Dosage and Administration
Adults (Age 13 years and older):
Upper respiratory tract infections,
100 mg 12 hourly for 5-10 days
Acute exacerbations of chronic bronchitis
200 mg 12 hourly for 10 days
Acute community-acquired pneumonia
200 mg 12 hourly for 14 days
Uncomplicated gonorrhoea
200 mg single dose
Uncomplicated urinary tract infections
100 mg 12 hourly for 7 days
Skin and skin structure infections
400 mg 12 hourly for 7 to 14 days
Children (Age 5 months through 12 years):
Acute otitis media
10 mg/kg (max 400 mg/dose) once daily or 5 mg/kg (max 200 mg/dose) 12 hourly for 10 days.
Pharyngitis and/or tonsillitis
5 mg/kg/dose (max 100 mg/dose) 12 hourly for 5-10 days.
Hepatic Insufficiency
No dosage adjustment is recommended for patients with hepatic insufficiency.
Renal Insufficiency
Dosage of cefpodoxime should be modified according to the degree of renal impairment for patients with creatinine clearance of less than 30 ml/minute.
Contraindications
Cefoprox is contraindicated in individuals who show hypersensitivity to cefpodoxime proxetil, to cephalosportins or other beta-lactamas.
Pregnancy:
Cefpodoxime may be administered to pregnant women only if clearly indicated.
Lactation:
Cefpodoxime is excreted in human milk. A decision should be made whether to discontinue nursing or to discontinue the drug.
Elderly:
No dose adjustment is recommended in elderly patients with normal renal function.
Pediactric Use:
Cefpodoxime proxetil is not recommended for infants under five months of age.
Side Effects
Adverse effects reported in clinical trials are mild and transient and include diarrhoea, nausea, vomiting, abdominal pain, colitis and headache. Rarely hypersensitivity reactions, rash, pruritus, dizziness, thrombocytopenia, leucopenia or eosinophilia may occur.
