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Anti Depressant
    Home > Anti Depressant > Zoloft (Sertraline)

Zoloft (Sertraline)
Select Ref Description Manufacturer Pack Size Strength Our Price
J317 Zoloft (Sertraline) Generic 10 tabs 25mg $ 3.36
J318 Zoloft (Sertraline) Generic 10 tabs 50mg $ 3.52
J319 Zoloft (Sertraline) Generic 10 tabs 100mg $ 4.20
Price is per pack & not per tab.. eg: if pack size is 10 tabs & price is $2.75 then for 100 tabs the price would be $27.50

What is Zoloft® and what does it treat?

Sertraline is an antidepressant medication that works in the brain.  It belongs to a class of medication known as selective serotonin reuptake inhibitor (SSRI) antidepressants.  Sertraline is approved for the treatment of Major Depressive Disorder (MDD), Post-traumatic Stress Disorder (PTSD), Premenstrual Dysphoric Disorder (PMDD), as well as Obsessive Compulsive Disorder (OCD) in adults and children.

Major Depression occurs when a person experiences at least five symptoms of depression, one of which must be either sad or depressed mood, or loss of interest in most activities. Other symptoms include changes in sleep (usually poor sleep); changes in appetite (usually decreased); loss of energy; feeling worthless/guilty/ hopeless/ helpless; psychomotor agitation or retardation (i.e. thoughts/movements speeding up or slowing down); difficulty concentrating; and thoughts of death (suicidal thinking). These symptoms must be present for a minimum of two weeks to satisfy the diagnosis of MDD.

PTSD occurs when a person experiences a traumatic event (e.g. assault, combat experience) and then later feels on edge; avoids situations that remind them of the event; and experiences flashbacks or nightmares.

PMDD occurs when a woman experiences symptoms including irritability, mood changes, bloating, tension, breast tenderness and sadness in association with the menstrual cycle.

OCD occurs when a person experiences the following symptoms at the same time: obsessions (unwanted, recurrent and disturbing thoughts) and compulsions (repetitive, ritualized behaviors that the person feels driven to perform in order to lessen the anxiety produced by the obsessions).

What is the most important information I should know about Zoloft®?

After starting sertraline, symptoms gradually decrease over a period of weeks.  Sleep and other physical symptoms may improve before there is noticeable improvement in mood or interest in activities.  Once symptoms are under control, MDD and other disorders sertraline is used to treat usually require long-term treatment to help prevent the return of symptoms.  Only your healthcare provider can determine the length of sertraline treatment that is right for you.

Do not stop taking sertraline or change your dose without talking to with your healthcare provider first.

Stopping sertraline abruptly may result in one or more of the following withdrawal symptoms: irritability, nausea, dizziness, vomiting, nightmares, headache and paresthesias (prickling, tingling sensation on the skin).

Because depression is also a part of Bipolar illness, people who take antidepressants may be at risk for "switching" from depression into mania. Symptoms of mania include "high" or irritable mood, very high self esteem, decreased need for sleep, pressure to keep talking, racing thoughts, being easily distracted, frequently involved in activities with a large risk for bad consequences (e.g. excessive buying sprees).

Are there specific concerns about Zoloft® and pregnancy?

If you are pregnant or are planning to become pregnant, it is very important to discuss the risks and benefits of taking sertraline with your provider. The FDA has classified sertraline as Category C in regards to pregnancy risk. This means that there have not been well-controlled studies in humans examining safety or that animal studies have demonstrated adverse effects to the developing fetus.

The benefits of sertraline in pregnancy may still be greater than the potential risks. For instance, if depression is left untreated during pregnancy, there is a high risk for poor prenatal care and premature delivery, and the babies may exhibit developmental delays in speech, intelligence, and socialization skills. Women who stop their antidepressants after learning of a pregnancy are five times more likely to relapse than pregnant women who continue their antidepressant.  Women who suffer with depression during their pregnancy are much more likely to become depressed postpartum as well.

As the risk for relapse or worsening depressive symptoms varies greatly among women during pregnancy, the decision to treat with antidepressants must be made on an individual basis. This decision is best made following thoughtful discussion with a trusted and informed health professional.

Regarding breast-feeding, it is believed that virtually all antidepressants (including sertraline) will pass into the breast milk. The concentrations in breast milk are generally quite low with sertraline even at higher doses and it would not be expected to cause adverse effects in babies. However, breastfeeding mothers should monitor their infants for behavioral side effects and adequate growth.

What should I discuss with my healthcare provider before taking Zoloft®?

The most bothersome symptoms of your condition and how often these have occurred in the past
If you have thoughts of suicide
Medications you have taken in the past for your condition, whether they were effective or caused any adverse effects
Any medical problems or medication allergies that you have
All other medications and nutritional/herbal supplements you are currently taking
If you are pregnant, plan to become pregnant, or are breast-feeding
Use of alcohol or recreational drugs (if applicable)

How should I take Zoloft®?

Sertraline is usually taken once daily (at the same time each day).  It may be taken with food to minimize stomach upset.

While the dose usually ranges from 50 mg to 200 mg, your healthcare provider will determine the dose that is right for you based upon your response.

When used for PMDD, sertraline may be taken continuously (every day) or intermittently (usually starting 14 days prior to the anticipated onset of menstruation through the first full day of menses and repeating with each cycle).  Your healthcare provider will determine the regimen that is right for you.

If you are taking the sertraline oral concentrate, mix your prescribed dose with 4 ounces (oz) of water, ginger ale, lemon-lime soda, lemonade or orange juice. Take it immediately after mixing it with your beverage. Do not mix it with anything other than the liquids listed. Do not mix your dosage in advance. A slight haze may appear after mixing; this is normal. Note that caution should be exercised with latex sensitivity, as the dropper dispenser provided with sertraline oral concentrate contains dry natural rubber.
What happens if I miss a dose of Zoloft®?

If you miss a dose of sertraline, take it as soon as you remember unless it is close to when your next dose is due. If it is close to your next dose, wait until then to take the medication and skip the missed dose. Do not double your next dose or take more than your prescribed dose.
What should I avoid while taking Zoloft®?

Avoid drinking alcohol or using illegal drugs while you are taking antidepressant medications because the beneficial effects of the medication may be decreased and adverse effects may be increased (e.g. sedation).
What happens if I overdose with Zoloft ®?

If an overdose occurs, whether intentional or accidental, immediate medical attention may be necessary.  Call your doctor or emergency medical service (911).  You may also contact the poison control center (1-800-222-1222).

Symptoms of overdose include drowsiness, nausea, vomiting, abdominal pain, tremor, slow heart rate, and seizures. A specific antidote does not exist.

What are the possible side effects of Zoloft®?

Common: Side effects with sertraline are generally mild and are similar to those reported with other SSRI antidepressants.  The most commonly reported side effects are nausea, diarrhea, increased sweating, sleepiness, insomnia, tremor, dry mouth, headache, weight loss or gain, dizziness, and restlessness.  If you experience side effects after starting sertraline they will often improve over the first week or two as you continue to take the medication. Sexual side effects such as problems with orgasm or ejaculatory delay may also occur, and often do not diminish over time.

Rare: Other side effects which occur infrequently with sertraline include increased heart rate, low blood pressure, increased salivation, irregular menstrual cycle, increased frequency of urination, changes in taste, increased liver enzymes, increased bleeding (e.g. gums may bleed more easily), low sodium blood levels (signs may include headache, weakness, difficulty concentrating and remembering), and teeth grinding.
Are there any risks for taking Zoloft® for long periods of time?

To date, there are no known neurotoxic or permanent side effects associated with long term use of sertraline.  It is a safe and effective medication when used as directed.

What other drugs may interact with Zoloft®?

Sertraline should not be taken with or within two (2) weeks of taking monoamine oxidase inhibitors (MAOIs).  These include phenelzine (Nardil®), tranylcypromine (Parnate®), isocarboxazid (Marplan®) and selegiline (Emsam®).

Patients receiving warfarin therapy should be carefully monitored when sertraline is initiated or discontinued. Changes in bloodwork as well as increased bleeding have been reported when sertraline is co-administered with warfarin (Coumadin®), aspirin or pain relievers known as “NSAIDS” (Non-Steroidal Anti-inflammatory Agents).

Although rare, there is an increased risk of serotonin syndrome when sertraline is used with other medications that increase serotonin such as other antidepressants; migraine medications called “triptans” (e.g. Imitrex®); the analgesics tramadol (Ultram®) or meperidine (Demerol®); and the antibiotic linezolid (Zyvox®).

Always let your doctor know what other prescription, over-the-counter, and herbal medications you are taking.

Sertraline Oral Concentrate should NOT be taken in combination with disulfiram (Antabuse®) due to the alcohol content of the concentrate.

How long does it take for Zoloft® to work?

Disturbances in sleep, energy, or appetite may show some improvement within the first 1-2 weeks and can be an important early signal that the medication is working. Other symptoms such as depressed mood or lack of interest in activities may take 4-6 weeks before improvement is evident.

Like other medications used for anxiety disorders (e.g. PTSD, OCD) sertraline may take several weeks before it is fully effective.  It is important to give the medication sufficient time before judging whether or not it will work for a given person.


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