In age-related memory impairment has a positive effect on psychophysiological state of elderly people, improving memory and attention and increasing the velocity of psychomotor reactions and lability of nervous processes.
Enhances cognitive skill learning in healthy older adults
Showed a positive effect in restless legs syndrome
Dosage
Parkinson's disease
Administration of piribedil should be initiated with one tablet daily during the first week. Dosage should then be gradually increased every week until achieving the optimal therapeutic dose:
as monotherapy: three to five tablets in three to five doses daily.
in combination with L-dopa therapy: one to three tablets daily.
Other indications
One tablet daily at the end of the main meal. In severe cases: two tablets daily in two doses.
Adverse effects
Minor gastrointestinal upset (nausea, vomiting, flatulence, etc) in predisposed individuals, or when taken between meals: adjust dosage individually, and/or add domperidone (Motilium).
Orthostatic hypotension or drowsiness may occur, particularly in predisposed individuals (underlying condition or causative illness).
Interactions
Dopamine antagonists reduce the effect of piribedil.
Overdosage
At very high doses, piribedil has an emetic action on the chemoreceptor trigger zone (CTZ). Tablets will thus be rapidly rejected, which explains why no data are currently available concerning the risk of overdosage.
